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Patients have reported severe gastrointestinal complications including: Gastroparesis requiring hospitalization and feeding tubes Intestinal blockage (ileus) necessitating emergency surgery Cyclic vomiting syndrome causing severe dehydration Gallbladder disease requiring cholecystectomy Pancreatitis with potential for chronic complications Severe constipation leading to bowel obstruction The first major lawsuit filed by Jaclyn Bjorklund in August 2023 alleged that she developed severe gastroparesis after taking Ozempic and Mounjaro, experiencing symptoms so debilitating that she required hospitalization and could no longer maintain normal nutrition

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However, muscle loss often results from rapid weight loss, regardless of the method