Ali MRK, Rahman MA, Wu Y, Han T, Peng X, Mackey MA, et al
Laboratory investigations using ionizing radiation-induced senescent cells demonstrate that FOXO4-DRI causes p53 nuclear exclusion and mitochondrial targeting, validating the proposed mechanism of selective senescent cell elimination through targeted protein-protein interaction disruption
So, while the mechanism is persuasive, it is not quite at the level of, say, well-known medications that affect metabolism
2-4 weeks Skin feels smoother and better hydrated 4-8 weeks Firmness and tone start to look more even 3+ months Deeper, more lasting changes as collagen rebuilds Administration If your skin gets irritated, red, itchy, or flaky, stop using the cream and let your provider know