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For patients requiring additional therapeutic effect, the dose may be increased to 1 mg of semaglutide weekly after at least four weeks at the 0.5 mg dose

The metabolism and clearance of both components may be affected by significant liver disease, and patients with severe hepatic impairment should be monitored closely if treatment is deemed necessary

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The excessive accumulation of subcutaneous adipose tissue is closely related to metabolic syndrome, cardiovascular diseases, etc