Outcomes reflect key findings: limited efficacy for beta-blockers/ACEi [32], modest benefits for spironolactone (TOPCAT, 2014) [10], neutral results for sacubitril/valsartan (PARAGON-HF, 2019) [9], reduced heart failure (HF) events for SGLT2i (DELIVER/EMPEROR-Preserved, 2021-2022) [11,12], and improved quality of life (QoL), weight loss, C-reactive protein (CRP) reduction, and 6-minute walk test (6MWT) distance with semaglutide (STEP HFpEF, 2023) [16]
Because body weight fell faster than muscle mass, the muscle-to-body-weight ratio improved in three of the five cases
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