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On one hand, the nsp12 NiRAN domain is involved in the second step to catalyse the ppA to GpppA transfer through its newly identified GTase activity

Glutathione (GSH) is the most abundant intracellular thiol and a critical component of the cellular antioxidant defense system

It may downregulate ACTH release and affect cortisol dynamics, contributing to studies on neuroendocrine recovery and homeostasis under chronic or acute stress

The broad prediction intervals across all outcomes underscore that future research may reveal effects ranging from beneficial to potentially harmful, highlighting the necessity of individualized dietary advice and careful monitoring