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Studies with mutants and transgenic plants over- or under-expressing enzymes or metabolites of the AsA-GSH pathway have proved very well the co-relation between this pathway and stress tolerance (Gill and Tuteja, Each enzyme of the AsA-GSH pathway has various subcellular isoforms, which differ from each other with respect to their spatial and temporal expression

This opens up a new area in which a non-traditional target may be employed to inhibit protein turnover, although how this type of inhibitor could achieve specificity is not clear at present

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