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In rare cases, orlistat has been linked to liver damage

doi: 10.1186/s13073-017-0490-5 34 HijovE.BertkovI.tofilovJ

Whereas creatinine-based estimates of GFR are able to predict risks associated with declining kidney function when eGFR levels fall to 60 mL/min/1.73m2 or less, GFR estimates based on cystatin C level are predictive at approximately 85 mL/min/1.73m2

(5.1) Hyperglycemia or hypoglycemia with changes in insulin regimen: Make changes to a patients insulin regimen (e.g., insulin strength, manufacturer, type, injection site or method of administration) under close medical supervision with increased frequency of blood glucose monitoring