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Microbiota-based interventions to enhance GLP-1 RA efficacy (probiotics, prebiotics, postbiotics) Given the bidirectional interplay between GLP-1 RAs and the gut microbiota, increasing attention has been directed toward microbiota-targeted strategies to address key clinical challenges, such as inter-individual response variability and substantial weight regain after treatment discontinuation

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It should be noted, however, that ALDH1A1, but not CYP2E1, is a downstream target of NRF2, which was found to be activated in untreated GCLM KO mouse liver