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CAFs upon activation secretes growth factors, cytokines, and ECM molecules including TGF-, matrix metalloproteinases (MMPs), hepatocyte growth factor (HGF), and fibroblast growth factors (FGFs), which are implicated in tumor development, invasion, and metastasis (120)

Sirtuin 3 is required for osteogenic differentiation through maintenance of PGC-1-SOD2-mediated regulation of mitochondrial function

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At about 40 years of age, practically all patients with Down syndrome exhibit neuropathological changes typical for Alzheimers disease including -amyloid plaques and neurofibrillary tangles (Mann and Esiri 1989)