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Genetic variations in genes such as interferon regulatory factor 5 (IRF5), TLR4, and vitamin D receptor (VDR) are linked to susceptibility across different populations [38,39,40,41,42], with specific SNPs like rs3807306 and rs4728142 associated with protective and risk factors, respectively [38]

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These oxidative modifications can lead to the aggregation and dysfunction of these proteins, compromising the structural integrity of the sperms cytoskeleton and impairing motility