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The doses sound impressive, but without liposomal or other bioavailability-enhancing technology, a large fraction of that dose is degraded before it reaches systemic circulation

Otoupal et al

Rockville, MD: MOPHP

This suggests that M pro might be particularly efficient at disrupting GSH synthesis, as compared to action at some of the other target sites predicted here, thereby contributing to the clinical findings in COVID-19 ( Finally (Figure 2D), we include a non-canonical hit that would cleave at position 90 of glutaredoxin-1 (GLRX-1)