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The ensuing negative feedback loop may involve not only EECs but also Paneth cells and intestinal intraepithelial lymphocytes, as these cells have been reported to express the receptor for GLP-1 (namely GLP-1R), and loss of GLP-1R increases the severity of DSS-induced intestinal injury8, 9

Other commonly reported effects include: Temporary fatigue (first few days) Occasional digestive discomfort Mild headache These effects usually resolve on their own and decrease with consistent use

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Psychiatry Neurosci