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In U87 cells, treatment with AKT inhibitor (HY-10249D) resulted in downregulation of GLUT1 and GLUT6 expression, while SREBP2 expression was downregulated (Fig

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Based on these data, together with the earlier studies on the specificity of monomeric macrocycle binding to Met, we conclude that the observed downstream phosphorylation events are triggered by the specific activation of Met by the dimeric macrocycles

Consult a licensed healthcare professional before starting any peptide protocol or making changes to your skincare routine, especially if you are pregnant, breastfeeding, or have an underlying medical condition