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About 1 in 8, or 12%, reported ever taking the "increasingly popular class of prescription drugs [GLP-1] used for weight loss and to treat diabetes or prevent heart attacks or strokes for adults with heart disease," according to the KFF Health Tracking Poll May 2024

Oxidative stress leads to imbalances in seminal plasma antioxidants, which is the main mechanism of a high semen viscosity, resulting in sperm DNA damage, sperm chromatin instability, membrane lipid peroxidation, and a low fertilization rate (Figure 1) (58)

Starting at a lower dose (e.g., 2 mg instead of 4 mg) helps reduce gastrointestinal side effects such as nausea, vomiting, diarrhea, and constipation, which are more common with higher initial doses