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During the 18-month observation period, oral semaglutide demonstrated significant reductions in HbA1c, with a maximum change of 0.9%, and 42.1% of patients achieved HbA1c values below 7.0%

In STEP-4 (NCT03548987), maintenance semaglutide after 20 weeks for another 48 weeks led to a further 7.9% bodyweight loss for a total 17.4% weight loss over the whole trial, whereas those who switched to placebo regained an average 6.9% (total weight loss of 5.0%) [66]

A cross-sectional study has demonstrated a notable association between serum Zn concentrations and thyroid volume in patients suffering from nodular goiter