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Notably, emerging evidence suggests that excitotoxicity may synergize with immune dysregulation, exacerbating neuronal vulnerability and accelerating disease progression [99]

The pathological process starts with the entry of virus particles in the upper respiratory tract epithelial cells via angiotensin converting enzyme 2 (ACE2) [110]

Selective NNMT inhibitors (including 5-Amino-1MQ) lower 1-MNA, increase NAD and SAM, suppress adipocyte lipogenesis, and reverse HFD-induced obesity in mice [1]