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Contraindication Screening Personal or family history of medullary thyroid carcinoma, MEN2 syndrome, prior pancreatitis, and severe gastroparesis are absolute or relative contraindications to GLP-1 therapy per the FDA label and Endocrine Society guidance 23

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Energy and fatigue changes GLP-1 related fatigue affects approximately 11% of users in clinical trials, and it tends to recur with each medication change