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Pigmentation disorders are the third most common reason for dermatological consultations ( 2.2.1 Ultraviolet exposure UV exposure is critical to skin pigmentation (Koike and Yamasaki, 2020

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After its synthesis, GSH is delivered to other intracellular compartments, including mitochondria, endoplasmic reticulum, nucleus, and to the extracellular space (e.g., blood plasma and bile) for utilization by other cells and tissues (Figure 1B)

Some of these chemical messengers are free radicals, which are highly reactive species that can either gain or loose electrons, or in proper terminology, take part in oxidation or reduction reactions