Frasca D, Landin AM, Lechner SC, Ryan JG, Schwartz R, Riley RL, et al
Regulation of Transmembrane Signaling by Phase Separation
Subsequently, the sections were deparaffinized through a graded series of ethanol (100%, 70%, 30%) and finally rinsed in PBS, each step lasting 5 min
Excess ROS then activates the NLRP3 inflammasome in microglia, promoting maturation and release of IL-1 ( 4.3 GSH metabolism: a central hub in mid-late SAE The hippocampus, with its high metabolic demands and low antioxidant capacity, is uniquely vulnerable to septic injury ( A Stat1-Gpx3 hub was identified, where TNF-/IL-1-induced Stat1 activation suppresses Nrf2 (confirmed by reduced hippocampal Nrf2)