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Hesperidin and related flavonoids are found in a variety of plants, but especially in citrus fruits, particularly their peels (Umeno 2016

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However, studies so far regarding inflammatory forms of SFN highlight the unpromising results of immunosuppressive therapies, including glucocorticoids [8], immunoglobulin [8], and rituximab, an anti-CD20 monoclonal antibody related to the inhibition of B-lymphocytes [27]