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Components of apical junction complexes retain an anchored position in the cell membrane by establishing interconnective networks between adjacent cells and associating with intracellular adaptor proteins linked to the intracellular cytoskeleton (Zihni et al

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Because MPNSTs may grow aggressively, local invasion into surrounding tissues such as bone, muscle, or organs can lead to secondary symptoms like swelling, restricted range of motion, or systemic signs such as fatigue or unintended weight loss, especially in advanced cases