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The overall pattern is consistent: most gastrointestinal side effects peak during dose escalation, diminish within weeks, and become minimal at stable maintenance doses

This short washout period helps ensure the first medication is cleared from your system, reducing the chance of overlapping side effects

But other factors influence how much, or how often, you eat

Tapering semaglutide to the most effective dose: real-world evidence from a digital weight management programme (TAILGATE) by Sren Seier, Kine Stamp Larsen, Jesper Pedersen, Jorne Biccler and Henrik Gudbergsen, April 2024, European Congress on Obesity (ECO2024)