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Apremilast is often well-tolerated and possesses a good safety profile relative to conventional systemic treatments

These therapies are especially helpful when used alongside testosterone replacement therapy and GLP-1 medications like semaglutide (Ozempic) or tirzepatide (Zepbound), where supporting muscle, hydration, and nutrient status becomes even more important

Ferroptosis, a recently discovered iron-dependent form of nonapoptotic cell death, has been associated with neurodegeneration and p53-mediated tumour suppression 28,29