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What has been established is that DSIP modulates multiple neurochemical and endocrine pathways including interactions with the hypothalamic-pituitary-adrenal (HPA) axis, endogenous opioid systems, and antioxidant defence mechanisms giving it a uniquely broad functional profile for a peptide of only nine amino acids

In wild type Xanthi NN tobacco NtPR-1a transcript levels were already induced in response to an 8 h exposure to SA but not OTC, while 24 and 48 h of both SA and OTC treatments resulted in elevated expression of NtPR-1a , especially in the case of SA exposure