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Adv Genet

(the significance of a high cobalaminconcentration in blood) Ermens AAM, Vlasveld LTh, Van Marion-Kievit JA, Lensen CJPA, Lindemans J

It is particularly important for neurological and cognitive health

1 Introduction Cisplatin is a chemotherapeutic agent that is widely used as an antitumor agent for the treatment of various types of cancers, such as ovarian, prostate, testicular, lung, nasopharyngeal, esophageal, lymphoma, squamous cell carcinoma of the head and neck, and osteogenic sarcoma ( Given the key role of oxidative stress in CIO, antioxidants have been used as otoprotective agents in a large number of studies targeting the prevention of cisplatin-induced hearing loss, such as N-acetylcysteine, sodium thiosulfate, amphotericin, vitamins, statins, dexamethasone, D-methionine, and ginkgo biloba extract ( in vitro experiments, and only a few clinical trials have been conducted