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Compared with the value of BMI, the metabolism and distribution characteristics of lipids will also have different effects on diabetes and CVD

HMGB1 binds to its receptor, namely receptor for advanced glycation end products (RAGE) to trigger the downstream inflammatory response and produce various pro-inflammatory mediators, like tumour necrosis factor-alpha (TNF-) and interleukin-1beta (IL-1), leading to neuroinflammation and neuronal apoptosis (Lotze and Tracey 2005)

Five studies could not be included in the quantitative synthesis because they did not report depressive-symptom outcomes with the summary statistics needed to calculate the effect size

Sonderby et al., 2010)