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It plays a crucial role in: Neutralizing free radicals Supporting liver detoxification Protecting skin cells from oxidative stress Maintaining overall cellular health Over time, factors like pollution, stress, aging, UV exposure, and poor sleep reduce glutathione levels

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However, as recently reviewed, the role of OCTN2 in breast cancer, either ER+ or ER-, is not straightforward when considering prognosis and patient survival after cancer treatment

Adjunctive approaches involving topical calcineurin inhibitors or corticosteroids in conjunction with phototherapy have yielded improved regimentation outcomes [209, 210], while emerging combinations with antioxidants and laser therapies offer additional therapeutic potential, albeit with limited clinical data to date [211]