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The presence of PD-L1 on LECs induces T cell tolerance through PD1/PD-L1 interaction and lack of co-stimulation (98), thus restricting CD8+ T cell activation and reducing their accumulation in the tumor microenvironment (95)

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Rhonda: So thats-thats kind of the-the those adaptations that occur

However, these same pathways can theoretically accelerate tumor growth or reawaken dormant cancer cells in individuals with active malignancy or recent remission