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An assortment of epidemiological and clinical studies have stated glucose and lipid metabolism alterations, insulin resistance, and central obesity as predominant factors for the development of MetS [38, 212]

It is widely used in the medical and cosmetic industries as a dietary supplement, disease treatment, skin whitener and weight loss product

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Additionally, based on the ERK5-on-target binding assay (KINOMEscan), RNK06138 showed no off-target kinase inhibition at the concentration used (1 M, Fig