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Acknowledgements We acknowledge that English language were edited by professor Jiang-Zhang from Guangxi Medical University, who is jointly awarded PhD degree by University of Florence, University of Pisa and University of Siena in Italy, and professor Jun Wu from City of Hope National Medical Center of The United States of America

By targeting two key metabolic hormones, it has demonstrated remarkable efficacy in promoting body weight reduction

Hui Jiang (Peking University First Hospital, Beijing, China) for his technical assistance on sperm count and motility assessment, and for his kindly gift of GC-1, GC-2, TM3 and TM4 cell lines