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[1] [3] For chronic weight management (Zepbound) , eligibility criteria include: Adults with BMI 30 kg/m (obesity), OR Adults with BMI 27 kg/m (overweight) with at least one weight-related comorbid condition such as hypertension, type 2 diabetes, or dyslipidemia Patients must be willing to engage in lifestyle modifications including reduced-calorie diet and increased physical activity

Maintaining regular physical activity, social engagement, and sleep hygiene helps distinguish treatment-related mood changes from other contributing factors