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The N-methylhistamine is further broken down with the MAO-B enzyme, forming N -methylimidazole acetaldehyde.[ref] Histamine (from body cells) [HNMT enzyme] N-methylhistamine [MAO-B enzyme] N-methylimidazole acetaldehyde Note that the HNMT enzyme (histamine N-methyltransferase) facilitates the transfer of a methyl group in the breakdown of histamine through this pathway

Key Facts Research compound used in metabolic studies Not approved for cosmetic application Works on appetite regulation pathways in clinical settings In skincare discussions, it is sometimes incorrectly grouped with peptide serums, but this is scientifically inaccurate

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In a further study Nonami et al