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Early approaches aimed to promote antioxidant activity for anti-cancer effect targeted antioxidants and ROS-scavenging systems, such as superoxide dismutase (SOD), glutathione peroxidases, peroxidoxins, glutaredoxin, thioredoxin, catalase, and nuclear factor erythroid 2-related factor 2 (Nrf2)

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While tirzepatide therapeutically slows gastric emptying as part of its mechanism of action, this pharmacological effect differs fundamentally from gastroparesis as a disease state