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Lola Fs, Monika Tu, Karolina Kaczmarska, Katarzyna Sanchez, Abhiyan Viplav, Ph.D., Tina el, Rositsa Hadzhipetrova #InSphero #LiverSafety #InVitroToxicology #Hepatotoxicity #DILI #3DCellCulture To view or add a comment, sign in A compound clears safety pharmacology, then Phase 1 comes back with diarrhea and related adverse events

The mechanism of this pathway requires a high concentration of glucose which is then converted to sorbitol by utilizing the enzyme Aldose reductase requiring coenzyme NADPH oxidized to NADP + (Yan 2018)

2019;11:S1262-3636

From an analytical point of view, our test is simple, fairly fast, sensitive and does not require large volume of sample