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The three-amino-acid truncation transforms IGF-1 from a highly regulated, IGFBP-bound mediator into a potent, locally-acting growth factor with minimal systemic distribution

are researchers and principals of Ingenious Ingredients, the sponsor of the study, and inventors of numerous patent applications for the use of paraxanthine but have been involved in data collection or analysis

This finding does not establish causality, but it is consistent with a model in which robust mitochondrial peptide signaling is a feature of successful aging rather than a peripheral correlate

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