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[PMC free article: PMC5822184] [PubMed: 29275363] [CrossRef] 199

Peptide-based drugs often require injection because: They degrade easily outside controlled environments They are too large to cross intact skin barriers Stable blood levels are difficult to maintain via topical application The Johns Hopkins Medicine resource on obesity management reinforces that medically supervised pharmacotherapy is part of comprehensive care rather than a standalone quick fix

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With the recent increase in prescriptions, 1 a notable gap in the literature still exists regarding comprehensive evaluations and comparisons of cutaneous reactions in this medication class