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Anesthesiology 128, 728744

In certain instances, a change in the ionic composition of inner ear fluids results in hearing loss, loss of balance and/or ossification of auditory structures

Studies in adults suggest that caffeine intake also directly affects the visceral and liver fat deposition, which are strong risk factors for cardio-metabolic disease (Figure 4)

PKM2 exhibits distinct oligomeric states with differential biological activities, of which its dimeric form displays low enzymatic activity, promotes metabolic dysregulation, and undergoes nuclear translocation for facilitating transcriptional co-activation, whereas the tetrameric state with high enzymatic activity suppresses the Warburg effect