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In addition, the composition of multiple constituents of Pycnogenol , each having different benefits for human health, further explains its broad clinical application ( For the first time, this review aims to systematically summarize and discuss these gold standard RDP trials comparing the efficacy of Pycnogenol to placebo and giving explanations for the different effects with the help of the respective mechanisms of action

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Consistently with the noted effect in rats with cauterized episcleral veins and glaucoma, BPC 157 without affecting the normal pupil, counteracted miosis produced by L-NAME, and miosis produced by L-arginine, as well as atropine-induced mydriasis [12]