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The cAMP/PKA pathway inhibits voltage-gated potassium channels that respond to depolarization, opens and allows K + efflux, repolarizing the cell and allowing increased calcium influx through voltage-dependent calcium channels, resulting in the exocytosis of insulin from -cells (115)

Since the promoter region of MITF contains the consensus CRE sequence, the expression of MITF can also be increased by -MSH stimulation in a cAMP-dependent manner (23)