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Patients with Lebers hereditary optic neuropathy should not receive B12 due to the risk of optic nerve damage

doi: 10.1016/j.immuni.2021.04.022 98 WongCKMcLeanBABaggioLLKoehlerJAHammoudRRittigNet al

15 The gene for glutathione peroxidase-4 is expressed in most tissues, including the brain (Gene Expression Atlas, available at Although the GPX4 gene is highly polymorphic, a limited number of studies 16, 17, 18, 19 have been done to investigate genetic variations within the GPX4 gene that could potentially alter the function of the enzyme