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Despite a large amount of effort and many publications, most studies have testified effects of the extract pretreatment prior to acute APAP administration on serologic, histologic, and morphologic liver-related outcomes in vivo , but few studies have explored these effects in hepatic cell lines by culturing with the natural products and administrating APAP

Various studies have explored ways to harness healthy astrocytes for neurodegenerative disease therapies, focusing on enhancing their metabolic functions, restoring normal receptor and transporter activity or utilizing their neuroprotective properties 125

To reduce gelification risk: use adequate solvent volume (avoid high concentrations), mix gently, allow equilibration at room temperature, and apply slight warming if needed

while in another study, lycopene was observed to suppress hepatic fibrogenesis, suggesting that lycopene may exert its positive effect on OSF by inhibiting fibrosis (Figure 4)