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As the primary factors for the reduced anticancer effect 1) the reduced delivery and uptake of the anticancer agent, 2) the need for the conversion of molecular oxygen (O 2 ) into reactive oxygen species (ROS), 3) the preferred therapeutic effect against highly proliferating cells, which is reduced under hypoxic conditions, or 4) adaptation of the cancer cells by promoting cell survival and upregulating certain resistance pathways, has been suggested 1,2,3,4,5

However, factors such as vaccination, subsequent infection waves or social influences, such as post-traumatic stress disorder, physical inactivity, and lack of exercise during lockdowns may have confounded reports of emotional or cognitive symptoms, which may not be a true reflection of post-C OVID conditions (187)

The treatment plan is determined based on the stage of the disease, vein structure, and the patients overall health

Anti-oxidant effect of gold nanoparticles restrains hyperglycemic conditions in diabetic mice