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Validation and sensitivity analysis The causal effects of genetically proxied GIPR/GLP-1R, GCGR/GLP-1R, and GCGR/GIPR/GLP-1R agonists on T2DM and MASLD were all well replicated in independent cohorts and showed consistent estimates in multiple sensitivity analyses in terms of magnitude and direction (Table 1)

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International society guidelines published prior to this date were reviewed from the American Academy of Neurology (AAN), European Academy of Neurology (EAN), and Japanese Society of Neurology, as well as national guidelines from Canada and Iran