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In addition to the KEAP1-dependent pathway, NRF2 degradation is regulated by an additional -TrCPdependent degradation pathway, via NRF2 phosphorylation by GSK3 in a PI3K-dependent manner (Hayes et al., 2015)

Similarly, Figure 2E focuses on TAO kinase 2 (TAOK2), a protein closely linked to tau phosphorylation and microtubule stability

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