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Many studies have shown that the cytoplasmic domain of the integrin 1 subunit can bind to cytoplasmic proteins to link integrins with the cells cytoskeleton and specific signaling pathways [62]

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In contrast, the non-dihydropyridine CCAs (verapamil, diltiazem) have the strongest affinity to the myocardium 2,4,6 and are used to treat angina or cardiac arrhythmias

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Pharmacol Rep 2011, 63 (4), 849858

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