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The impact of PD-1 expression is also related to the aging of immune cells in the development of diabetes 46

Patent expiries of blockbuster weight loss GLP-1 (glucagon-like peptide-1) drugs are opening up a sizeable near-term opportunity for Indian pharmaceutical companies in regulated markets, led by Canada and Brazil, with a potential generic market value of about $500 million, according to Vishal Manchanda, Pharma Analyst at Systematix Group

This would be in line with preclinical observations that incretin receptor expression is down-regulated by exposure to high glucose, and improves once normoglycaemia is restored (48), and that dys-regulation of glycaemic control in otherwise healthy humans leads to impaired incretin actions (49)