biology of incretins glp 1 and gip Gastrointestinal Incretins—Glucose-Dependent Insulinotropic Polypeptide (GIP) Glucagon-like Peptide-1 (GLP-1) beyond Pleiotropic Physiological Effects Are Involved in Pathophysiology Atherosclerosis and Coronary Artery Disease—State of the Art GLP-1 & GIP Agonists |

In the rat pancreas, somatostatin tonically inhibits glucagon secretion and is required for glucose-induced inhibition of glucagon secretion

All three are GHS-R1 agonists

[side note: Ozempic and Wegovy are the brand names of semaglutide - named differently depending on dose and indication: Ozempic is for type 2 diabetes and can be given up to a 2 mg dose, while Wegovy is for obesity at a 2.4 mg dose] As a PWS researcher that has focused on understanding PWS hyperphagia, I am ecstatic to see this type of progress in anti-obesity pharmaceutical development

Recent studies suggest that GLP-1R lacks kinase activity, and may rely on EGFR to promote proliferation 29