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Most familial cases of both ALS (~40%) and FTD (25%) are associated with hexanucleotide (G4C2) expansions in the Chromosome 9 open reading frame 72 (C9orf72) gene (Dejesus-Hernandez et al., 2011

Commercial products use various concentrations based on extrapolation from preclinical data rather than human optimization studies

HIF proteins are dimers consisting of an subunit, which is generally inactivated by prolyl hydroxylase dioxygenase (PHD) under normal oxygen conditions (160), and a subunit, which binds to the active subunit under hypoxic conditions, allowing the complex to move into the nucleus freely (161, 162)

To summarise, more research should be done to comprehensively analyze the risk factors of ipamorelin use