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(2021) trial tested cagrilintide at 0.3-4.5 mg weekly for 26 weeks in 706 adults: (Lau et al., 2021) Semaglutide Monotherapy (Phase 3) The STEP 1 trial tested semaglutide 2.4 mg weekly for 68 weeks in 1,961 adults: Mean weight loss: -14.9% =10% threshold: ~70% =15% threshold: ~54% =20% threshold: ~32% Important caveat: The semaglutide trial was 68 weeks versus only 26 weeks for cagrilintide

In addition to dedifferentiation, another consequence of in vitro expansion is replicative senescence, which also significantly influences chondrocyte function

This non-linear dose-response is characteristic of peptides that operate through receptor saturation rather than systemic hormonal signalling

The most common side effects are injection site pain, redness, and transient warmth at the injection area