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It involves the direct action of the GLP-1 agonist component on the hearts pacemaker cells, combined with the chronotropic (heart rate-increasing) effects of the glucagon agonist component

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(2025) 48:S20738

Of note is that the observed median time to onset of the psychiatric AEs in our analysis of the FAERS data aligned with common gastrointestinal AEs such as nausea and vomiting, which were the most frequently reported within the first 30 days of GLP-1 RA treatment ( In this extensive pharmacovigilance study, we observed a significant association between GLP-1 RAs and eight distinct categories of psychiatric AEs, namely, nervousness, stress, eating disorder, fear of injection, sleep disorder due to general medical conditioninsomnia type, binge eating, fear of eating, and self-induced vomiting